pubmed link for complete list of publicationS

Zhang lab members: marked in bold | # Co-first author | * Corresponding author


  • Watson ER, Grace CRR, Zhang W, Miller DJ, Davidson IF, Prabu JR, Yu S, Bolhuis DL, Kulko ET, Vollrath R, Haselbach D, Stark H, Peters JM, Brown NG, Sidhu SS, Schulman BA. (2019) Protein engineering of a ubiquitin-variant inhibitor of APC/C identifies a cryptic K48 ubiquitin chain binding site. Proc. Natl. Acad. Sci. U.S.A. 116, 17280-17289.

  • Gabrielsen M#, Buetow L#, Kowalczyk D#, Zhang W, Sidhu SS, Huang DT. (2019) Identification and Characterization of Mutations in Ubiquitin Required for Non-covalent Dimer Formation. Structure 27, 1452-1459.

  • Veggiani G#, Gerpe MCR#, Sidhu SS*, Zhang W*. (2019) Emerging drug development technologies targeting ubiquitination for cancer therapeutics. Pharmacology & Therapeutics 199, 139-154.

Before coming to University of guelph:


  • Zhang W*, Sidhu SS*. (2018) Generating Intracellular Modulators of E3 Ligases and Deubiquitinases from Phage-Displayed Ubiquitin Variant Libraries. Methods in Molecular Biology 1844, 101-119. This is a book chapter in: Mayor T., Kleiger G. (eds) The Ubiquitin Proteasome System. Humana Press, New York, NY

  • Zhang W, Sidhu SS. (2018) Drug development: Allosteric inhibitors hit USP7 hard. Nature Chemical Biology 14, 110-111.

  • Ordureau A, Paulo JA, Zhang W, Ahfeldt T, Zhang J, Cohn EF, Hou Z, Heo JM, Rubin LL, Sidhu SS, Gygi SP, Harper JW. (2018) Dynamics of PARKIN-Dependent Mitochondrial Ubiquitylation in Induced Neurons and Model Systems Revealed by Digital Snapshot Proteomics. Molecular Cell 70, 211–227.

  • Canny MD, Moatti N, Wan LC, Fradet-Turcotte A, Krasner D, Mateos-Gomez P, Zimmermann M, Orthwein A, Juang YC, Zhang W, Noordermeer SM, Seclen E, Wilson MD, Vorobyov A, Munro M, Ernst A, Ng TF, Cho T, Cannon P, Sidhu SS, Sicheri F, Durocher D. (2018) Inhibition of 53BP1 favors homology-dependent DNA repair and increases CRISPR-Cas9 genome-editing efficiency. Nature Biotechnology 36, 95–102.


  • Gabrielsen M, Buetow L, Nakasone MA, Ahmed SF, Sibbet GJ, Smith BO, Zhang W*, Sidhu SS*, Huang DT*. (2017) A general strategy for discovery of inhibitors and activators of RING and U-box E3 ligases with ubiquitin variants. Molecular Cell 68, 456-470.

  • Zhang W, Ben-David M, Sidhu SS. (2017) Engineering cell signaling modulators from native protein-protein interactions. Current Opinion in Structural Biology 45, 25-35.

  • Zhang W, Sartori MA, Makhnevych T, Federowicz KE, Dong X, Liu L, Nim S, Dong A, Yang J, Li Y, Haddad D, Ernst A, Heerding D, Tong Y, Moffat J, Sidhu SS. (2017) Generation and validation of intracellular inhibitors for USP7 and USP10. Journal of Molecular Biology 429, 3546-3560.

  • Zhang W, Bailey-Elkin BA, Knaap RCM, Khare B, Dalebout TJ, Johnson G, van Kasteren PB, McLeish N, Gu J, He W, Kikkert M, Mark BL, Sidhu SS. (2017) Potent and selective inhibition of pathogenic viruses by engineered ubiquitin variants. PLoS Pathogens 13(5): e1006372.


  • Yamaguchi M, Vanderlinden R, Weissmann F, Qiao R, Brown NG, Dube P, Haselbach D, Zhang W, Sidhu SS, Peters JM, Stark H, Schulman BA. (2016) Cryo-EM of mitotic checkpoint complex-bound APC/C reveals reciprocal and conformational regulation of ubiquitin ligation. Molecular Cell 63, 593-607.

  • Brown NG, Vanderlinden R, Watson E, Weissmann F, Ordureau A, Wu KP, Zhang W, Yu S, Mercredi PY, Harrison JS, Davidson IF, Qiao R, Lu Y, Dube P, Brunner MR, Grace CRR, Miller DJ, Haselbach D, Jarvis MA, Yamaguchi M, Yanishevski D, Petzold G, Sidhu SS, Kuhlman B, Kirschner MW, Harper JW, Peters JM, Stark H, Schulman BA. (2016) Dual RING E3 architectures regulate multiubiquitination and ubiquitin chain elongation by APC/C. Cell 165, 1440-1453.

  • Zhang W, Wu KP, Sartori MA, Kamadurai HB, Ordureau A, Jiang C, Mercredi PY, Murchie R, Hu J, Persaud A, Mukherjee M, Li N, Doye A, Walker JR, Sheng Y, Hao Z, Li Y, Brown KR, Lemichez E, Chen J, Tong Y, Harper JW, Moffat J, Rotin D, Schulman BA, Sidhu SS. (2016) System-wide modulation of HECT E3 ligases with selective ubiquitin variant probes. Molecular Cell 62, 121-36. ⌘ Highlighted in the issue with accompanied preview: Canadeo LA, Huibregtse JM. (2016) A billion ubiquitin variants to probe and modulate the UPS. Molecular Cell 62, 2-4.

  • Bahn RS, Iorio C, Marcotte R, Xu Y, Cojocari D, Rahman AA, Pawling J, Zhang W, Sinha A, Rose CM, Isasa M, Zhang S, Wu R, Virtanen C, Hitomi T, Habu T, Sidhu SS, Koizumi A, Wilkins SE, Kislinger T, Gygi SP, Schofiled CJ, Dennis JW, Wouters BG, Neel BG. (2016) PTP1B controls non-mitochondrial oxygen consumption by regulating RNF213 to promote tumour survival during hypoxia. Nature Cell Biology 18, 803-813.

  • Strecker J, Gupta GD, Zhang W, Bashkurov M, Landry MC, Pelletier L, Durocher D. (2016) DNA damage signalling targets the kinetochore to promote chromatin mobility. Nature Cell Biology 18, 281–290.


  • Chung DKC, Chan JNY, Strecker J, Zhang W, Ebrahimi-Ardebili S, Lu T, Abraham KJ, Durocher D, Mekhail K. (2015) Perinuclear tethers license telomeric DSBs for a broad kinesin/NPC-dependent DNA repair process. Nature Communications 6:7742 doi: 10.1038/ncomms8742

  • Zhang W, Sidhu SS. (2014) Development of inhibitors in the ubiquitination cascade. FEBS Letters 588, 356-67.

  • Zhang W, Durocher D. (2010) De novo telomere formation is suppressed by the Mec1-dependent inhibition of Cdc13 accumulation at DNA breaks. Genes & Development 24, 502-15. ⌘ Highly recommended by Drs. Virginia Zakian (Princeton), David Shore (Geneva), and Katherine Friedman (Vanderbilt) on Faculty of 1000. ⌘ Featured as “Top 7 in Cancer Biology” in March 2011 by The Scientist magazine®

  • O'Donnell L, Panier S, Wildenhain J, Tkach JM, Al-Hakim A, Landry MC, Escribano-Diaz C, Szilard RK, Young JT, Munro M, Canny MD, Kolas NK, Zhang W, Harding SM, Ylanko J, Mendez M, Mullin M, Sun T, Habermann B, Datti A, Bristow RG, Gingras AC, Tyers MD, Brown GW, Durocher D. (2010) The MMS22L-TONSL complex mediates recovery from replication stress and homologous recombination. Molecular Cell 40, 619-31.

  • Mao DY, Neculai D, Downey M, Orlicky S, Haffani YZ, Ceccarelli DF, Ho JS, Szilard RK, Zhang W, Ho CS, Wan L, Fares C, Rumpel S, Kurinov I, Arrowsmith CH, Durocher D, Sicheri F. (2008) Atomic structure of the KEOPS complex: an ancient protein kinase-containing molecular machine. Molecular Cell 32, 259-75.

  • Zhang W, Durocher D. (2008) Dun1 counts on Rad53 to be turned on. Molecular Cell 31, 1-2.