Our Mission

Reprogramming Cell Signaling for New Knowledge and Innovative Therapeutics

General Workflow

Protein engineering.png

What We've Achieved

Systematic development of protein modulators for ubiquitin-interacting proteins

Zhang et al. Molecular Cell 2016 [Patent Pending]; Gabrielsen et al. Molecular Cell 2017

generated anti-viral reagents for Middle East respiratory syndrome (MERS) Coronavirus

Zhang et al. PLoS Pathogens 2017 [Patent Pending]

Created molecular tools to increase CRISPR-Cas9 genome-editing efficiency

Canny et al. Nature Biotechnology 2018 [Patent Pending]


What We'll Do

Development of intracellular probes to delineate biochemical mechanisms of E3 ubiquitin ligases

Engineering post-translational modifications to probe and rewire DNA damage signaling for cancer therapeutics

Improvement of CRISPR-based gene editing through directed evolution